Giant with a Startup’s Heart

Express Scripts is one of the biggest and fastest growing companies in the United States, but the history of the company is what makes it uniquely St. Louis.

Beginning in a cinder block building in St. Louis County, Express Scripts was founded on the simple idea that there was a better way to manage prescriptions. Channeling their innovations, Express Scripts transformed the home delivery of prescription medicine and grew from a startup to a corporate giant in just over 30 years. Today their focus is improving and ensuring the safety and affordability of prescription drugs.

Express Scripts’ latest expansion is a new lab that debuted in July, 2014. This recent expansion tops their total square footage at over one million. Their large presence is evident as you pass it driving east on I-70 from Lambert-St. Louis International Airport.


Express Scripts’ employee population is diverse:  70% are women; 35% are minority; 10% speak more than one language; and 75% are either GenX or Millenials. With plans to add 1,500 new jobs by 2018, that will bring their employees census to 6,000.

Express Scripts generates more than $1.5 billion in annual economic impact on St. Louis County, and that number is expected to continue to grow in the coming years. That’s one heck of a startup!

Similar to Express Scripts, Enterprise and WorldWide Technology in St. Louis focused on that same “one innovative principal” for their industry, and in a relatively short timeline have experienced the same dynamic growth and have greatly impacted the St. Louis economy.